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Alflutop is characterized by analgesic and anti-inflammatory action. Alflutop has chondroprotective influence, it effectively regulates cartilage metabolism. Chondroprotective drugs are based on the property of reducing the activity of specific enzymes, including hyaluronidases. These enzymes play a major role in stabilizing the biosynthesis of type II collagen and hyaluronic acid and are involved in the destruction of the extracellular matrix.
The drug reduces the destruction of macromolecular structure of the base material of the connective tissue, reduces the permeability of capillaries. Furthermore, Alflutop stimulate tissue repair process of the articular cartilage, and interstitial tissue. Proteoglycans, which are a component of the drug, cause the trophic effect. With a replacement effect, they greatly increase the performance of MRI-hydrophilic cartilage, its height and uniformity of bone tissue.
Due to this the medicament reduces pain force at rest and in motion. Significantly reduced pain when walking on a flat road, sometimes even while walking up the stairs. Markedly reduced the severity of contracture and local swelling. Thus Alflutop facilitates overall motility of affected joints, increases the volume of its movements.
Besides the drug reduces the globulins seromucoid, C-reactive protein, fibrinogen, and the number of leukocytes into the synovial fluid.
After treatment total duration of 6 months in the synovial fluid levels of hyaluronic acid is increased in two times. But the anti-inflammatory effect is noticeable already at 8 days of therapy.
Alflutop indications for use:
Alflutop prescribed for the following diseases and conditions:
- Osteoarthritis, primary and secondary, various sites, including arthritis of small joints, coxarthrosis and gonarthrosis;
- Traumatic dysostosis;
- Endochondral ossification and Chondral violations;
Alflutop is also administered in the recovery period after surgery, carried on the joints.
Alflutop mode of application:
Alflutop administered intramuscularly in the treatment of degenerative disc disease and polyosteoarthrosis. The dose is 1 ml per day. For one course of treatment must be made 20 drug injection.
If it affects the joints Alflutop administered intra-articularly. Each joint is required to introduce 2 ml per injection, which is carried out every three days. After 6 intra-articular injections should be continued administration of the drug intramuscularly. After 4-6 months of treatment should be repeated.
It is known that a significant effect is the combination of intra-articular and intramuscular injection Alflutop.
Alflutop side effects:
In the application of the drug as the side effects are the allergic reactions, itching, redness and irritation at the injection site, short-myalgia, arthralgia. In some cases, intraarticular injection Alflutop is amplification of pain, because it activates the metabolism and blood circulation is more intense.
Alflutop is contraindicated during lactation and pregnancy. It is forbidden to take Alflutop with hypersensitivity to its components.
Assigned to receive the drug for children and adolescents is not recommended, because there is no testing evidence on efficacy and safety of its use in this age group.
Alflutop during pregnancy:
It is forbidden to take Alflutop during pregnancy and lactation.
Alflutop interaction with other drugs:
Not applicable Alflutop drug interactions.
To date not provided any data on overdose of Alflutop
Alflutop product form:
Aflutop distributed as a solution for injection, a prisoner in 1ml ampoules. The cardboard package contains 10 vials.
Alflutop storage conditions:
Should be stored out of the reach of children, protected from light and heat. Storage temperature should be in the range of 8 ° to 15 ° C. The shelf life is 2 years Alflutop.
Alflutop is an extract from marine fish. The active portion of the formulation comprises hyaluronic acid, mucopolysaccharides, dermatan sulfate, chondroitin sulfate, sulfate kreatana, polypeptides, amino acids, magnesium ions, copper, iron, zinc, potassium and sodium. As excipients used for water injection and phenol.
Alflutop pharmacological group:
Analgesics and anti-inflammatory.
Used for rheumatic pains in the joints, muscle pain and neuralgia